HIGHLY EFFICIENT DELIVERY OF A LARGE THERAPEUTIC M

专利名称：HIGHLY EFFICIENT DELIVERY OF A LARGE

THERAPEUTIC MASS AEROSOL

发明人：EDWARDS, David, A.,BATYCKY, Richard,

P.,JOHNSTON, Lloyd

申请号：EP01942072.8申请日：20010608公开号：EP1296663B1公开日：20070321

摘要：A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing amass of particles, to a subject's respiratory tract, particles which have a tap density ofless than 0.4 g/cm3 and deliver at least about 50 % of the mass of particles. The particlesare capable of carrying agents. The agent is: 1) part of the spray-drying pre-mixture andthereby incorporated into the particles; 2) added to separately-prepared particles sothat the agent is in chemical association with the particles; or 3) blended so that theagent is mixed with, and co-delivered with the particles. Respirable compositions

comprising carrier particles having a tap density of less than 0.4 g/cm3 and a compositioncomprising an agent are also disclosed. Methods of delivering these respirablecompositions are also included.

申请人：ADVANCED INHALATION RES INC

地址：US

国籍：US

代理机构：Kirkham, Nicholas Andrew

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