Determination of polymerizationcoagulation in a f

专利名称：Determination of

polymerization/coagulation in a fluid

发明人：Pentti Tengvall,Ingemar Lundstrom申请号：US09622063申请日：20001114公开号：US06379976B1公开日：20020430

摘要：An analytical method of qualitative and optionally quantitative determination ofthe occurrence of polymerization/coagulation in a fluid containing

polymerizable/coagulable components is described. The method comprises the steps ofdirecting incident beams of electromagnetic radiation through a transparent support onwhich a film of electrically conducting material is placed, to the back of the film, at anglesequal to or greater than the critical angle for total reflection, and measuring changes inthe reflected beams due to changes in the surface plasmon resonance angle. Repeatedmeasurements are correlated to the occurrence and magnitude of changes withqualitative and optionally quantitative occurrence of polymerization/coagulation in thefluid. The analytical method is not volume dependent since only one (small) surface ofthe measuring instrument needs to be in contact with the fluid. Further, the method canalso be applied to poorly transparent fluids such as blood.

申请人：GLOBAL HEMOSTASIS INSTITUTE MGR AB

代理机构：Bacon & Thomas

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