Maternal_embryonic_leucine_zipper_kinase抑制剂_激动剂_MCE

Maternal embryonic leucine zipper kinase

MELK (Maternal Embryonic Leucine zipper Kinase) belongs to theCAMK serine/threonine protein kinase superfamily. Melk is a proteinserine/threonine kinase that is maximally active during mitosis. It isinvolved in diverse functions such as cell cycle, cytokinesis, mRNAsplicing and apoptosis. Expression MELK is expressed in cells ofvarious tissue origins. MELK expression is strongly dependant oncell-cycle: MELK is undetectable in cells which have exited cell cycle.The exact function of MELK is currently unknown, however MELK wasshown to be involved in cell cycle progression via the proteinphosphatase CDC25B phosphorylation, in cytokinesis, in apoptosis viaits interaction with the Bcl-2 family of proapoptotic genes and

apoptosis signal-regulating kinase (ASK1) and in inhibition of mRNA splicing during mitosis via its association withNIPP1. MELK function is required for mammary tumorigenesis in vivo.

www.MedChemExpress.cn1MELK Inhibitors & Modulators

OTSSP167(MELK inhibitor; OTSSP-167; OTSSP 167)Bioactivity:Cat. No.: HY-15512OTSSP167 is a highly potent MELK inhibitor (IC50 = 0.41 nM) andinhibited the phosphorylation of PSMA1 (proteasome subunit alphatype 1) and DBNL (drebrin-like).OTSSP167 hydrochloride (MELK inhibitor; OTSSP-167 hydrochloride; OTSSP 167 hydrochloride)Bioactivity:Cat. No.: HY-15512AOTSSP167 Hcl is a highly potent MELK inhibitor (IC50 = 0.41 nM) andinhibited the phosphorylation of PSMA1 (proteasome subunit alphatype 1) and DBNL (drebrin-like).Purity:>98%Clinical Data:Phase 1Size:2 mg, 5 mg, 10 mg, 50 mgPurity:>98%Clinical Data:Size:10mM x 1mL in DMSO,2 mg, 5 mg, 10 mg, 50 mg2Tel: 4008203792Fax: 021-53700325Email: sales@MedChemExpress.cn