Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :BIBR 1532321674-73-1HY-17353331.36C21H17NO3>98%Solubility:DMSO 100 mg/mL EthanolMechanisms: Pathways:Cell Cycle/DNA Damage; Target:Telomerase gyBiological Activity:BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM. IC50 Value: 100 nM Target: Telomerase BIBR 1532 is a selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM forhuman telomerase, human RNA polymerase I and human RNA polymerase II + III respectively).Studies indicate that BIBR 1532 inhibits the reverse transcriptase of telomerase, hTERT, andshortens the length of the telomere. In addition, reports indicate that BIBR 1532 has the ability tostop cell proliferation in lung cancer cell studies after 120 days. BIBR 1532 causes telomereppgyshortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest....References:[1]. El-Daly H, Kull M, Zimmermann S et al. Selective cytotoxicity and telomere damage in leukemiacells using the telomerase inhibitor BIBR1532. Blood. 2005 Feb 15;105(4):1742-9. [2]. Mueller S, Hartmann U, Mayer F et al. Targeting telomerase activity by BIBR1532 as atherapeutic approach in germ cell tumors. Invest New Drugs. 2007 Dec;25(6):519-24.pppgg() [3]. El Daly H, Martens UM. Telomerase inhibition and telomere targeting in hematopoietic cancercell lines with small non-nucleosidic synthetic compounds (BIBR1532). Methods Mol Biol.2007;405:47-60. [4]. Parsch D, Brassat U, Brümmendorf TH, Fellenberg J. Consequences of telomerase inhibition byBIBR1532 on proliferation and chemosensitivity of chondrosarcoma cell lines. Cancer Invest. 2008Jul;26(6):590-6. [5]. Bashash D, Ghaffari SH, Zaker F et al. Direct short-term cytotoxic effects of BIBR 1532 onacute...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 080,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr
