Methods and compositions for treating viral infect

专利名称：Methods and compositions for treating viral

infections

发明人：Thomas Albrecht,Odd S. Steinsland申请号：US06/601471申请日：19840418公开号：US04663317A公开日：19870505

摘要：The disclosure demonstrates the inhibition of replication of human

cytomegalovirus (HCMV) in cultured human embryo skin muscle cells by two separatesubclasses of direct-acting smooth muscle relaxing agents. These two subclasses arecharacterized mechanistically as calcium influx blockers (or calcium channel blockers) andcyclic nucleotide modulators. More specifically, the class of calcium influx blockers isexemplified by the drugs verapamil (and methoxyverapamil), nifedipine (the prototypedrug of 1,4 dihydropyridines), and diltiazem. The class of cyclic nucleotide modulators isexemplified by the drugs isobutylmethylxanthine, papaverine (and its synthetic analogdioxyline), forskolin, and sodium nitroprusside. All of these agents inhibit replication ofHCMV and HSV.

申请人：BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

代理机构：Arnold, White & Durkee

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