Use of L-Histidine and derivatives thereof

专利名称：Use of L-Histidine and derivatives thereof发明人：Baranyai Zsolt,Ernö Brücher,Simona

Bussi,Alessandro Maiocchi,Fulvio Uggeri

申请号：US14235128申请日：20120724公开号：US09012483B2公开日：20150421

摘要：The present invention discloses the use of L-Histidine to reduce Gadoliniumaccumulation into target organs, preventing its toxic effects, after administration ofgadolinium based contrast agents. The invention thus, also disclose the use of L-Histidineto prevent the NSF syndrome in patients with renal functionality impairment. A kit of partis also disclosed by the use of which toxicity associated to free Gd3+, deriving fromGDBCA, is prevented by oral administration of L-histidine before administration of thecontrast agent. A method for the prevention of toxic metal accumulation which consists inthe administration, preferably by the oral route, of L-Histidine is also disclosed. L-Histidine is preferably administered as a single oral dose comprised from 0.2-20 g.

申请人：Baranyai Zsolt,Ernö Brücher,Simona Bussi,Alessandro Maiocchi,Fulvio Uggeri

地址：Debrecen HU,Debrecen HU,Vercelli IT,Monza IT,Codogno IT

国籍：HU,HU,IT,IT,IT

代理人：M. Caragh Noone

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