4-(3-(4-oxothiazolidinyl)butynylamines

专利名称：4-(3-(4-oxothiazolidinyl)butynylamines发明人：Nicholas J. Hrib申请号：US07/509280申请日：19900416公开号：US05034392A公开日：19910723

摘要：This invention relates to compounds of the formula ##STR1## where R. sub.1and R.sub.2 are independently hydrogen or loweralkyl or R. sub.1 and R.sub.2 takentogether with the carbon atom to which they are attached form a spiro-fused cycloalkaneof 5 to 8 carbons; R.sub.3 and R. sub.4 are independently hydrogen or loweralkyl orR.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached forma spiro- fused cycloalkane of 5 to 8 carbons; R.sub.5 and R.sub.6 taken together with thenitrogen atom to which they are attached are ##STR2## where X in each occurrence isindependently hydrogen, halogen, loweralkyl, hydroxy, nitro, amino, cyano,

trifluoromethyl or methoxy; and m is 0, 1 or 2; the pharmaceutically acceptable acidaddition salts thereof and where applicable the optical and geometrical isomers andracemic mixtures thereof. The compounds of this invention are useful as analgesic andantihypertensive agents.

申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

代理人：Elliott Korsen

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