Recombinant Human Legumain (C-6His)

北京索莱宝科技有限公司RecombinantHumanLegumain(C-6His)Catalog#:P00079DerivedfromHumanCellsRecombinantHumanLegumain/AsparaginylEndopeptidaseisproducedbyourMammalianexpressionsystemandthetargetgeneencodingIle18-Tyr433isDESCRIPTIONexpressedwitha6HistagattheC-terminus.Accession#:Q99538Knownas:Legumain;AsparaginylEndopeptidase;ProteaseCysteine1;LGMN;PRSC1FORMULATIONSuppliedasa0.2μmfilteredsolutionof20mMTrisHCl,150mMNaCl,10%Glycerol,pH8.0.Theproductisshippedondryice/polarpacks.Uponreceipt,storeitimmediatelyatthetemperaturelistedbelow.Storeat<-20°C,stablefor6monthsafterreceipt.Pleaseminimizefreeze-thawcycles.MolMass：48.72kDaQUALITYCONTROLAPMolMass：56kDa,reducingconditions.SHIPPINGSTORAGEPurity:Greaterthan90%asdeterminedbyreducingSDS-PAGE.Endotoxin:Lessthan0.1ng/µg(1EU/µg)asdeterminedbyLALtest.LegumainisalysosomalcysteineproteasewhichisamemberofthepeptidaseC13family.Thoughitisfoundinmanytissues,itishighlyexpressedinthekidney,heart,andplacenta.LegumainhasastrictspecificityforhydrolysisofasparaginylbondsBACKGROUNDandcanalsocleaveaspartylbondsslowly,especiallyunderacidicconditions.Over-expressionLegumainintumorsissignificantforinvasionandmetastasis.Inaddition,LegumainmaybeinvolvedintheprocessingofproteinsforMHCclassIIantigenpresentationinthelysosomal/endosomalsystemandnegativeregulationofneuronapoptosis.1st北京索莱宝科技有限公司2nd